Clínica dental

STOPPING A GLOBAL KILLER – Georgia State University

[título_original] – Nueva actualización 2023

Somos un pequeño grupo de apasionados profesionales de la odontología que han estado escribiendo artículos para el público durante más de 10 años. Nuestra misión es proporcionar información precisa y actualizada sobre la salud bucal para que las personas puedan tomar decisiones informadas sobre su atención dental.
Sabemos que una excelente salud bucal es esencial para la salud y el bienestar general, y estamos comprometidos a ayudar a nuestros lectores a lograr y mantener dientes y encías saludables.

Portrait of a white man in a lab coat

Christopher Basler, professor and director of the Center for Microbial Pathogenesis, is among the researchers in the Institute for Biomedical Sciences who are building on their prior work to develop treatments and vaccines for the new coronavirus.

People have long wondered what the next dangerous pathogen would be.

While humans have encountered some deadly viruses over the centuries such as influenza, Ebola, smallpox, SARS, MERS and HIV, there are inevitably new, life-threatening diseases out there waiting to emerge. Experts have agreed that it wasn’t a question of if – but when – another lethal infectious agent would occur and speculated if the world would be ready to fight it. Sadly, the answer is no.

As the new year began, coronavirus disease 2019 (COVID-19), a novel, highly contagious disease that was first reported in Wuhan, China, caught the world off guard, rapidly spreading across the globe and causing an unprecedented public health crisis. In only months, COVID-19, which is caused by a new virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infected millions of people worldwide and killed nearly 205,000 (as of April 29, 2020).

The ominous disease was declared a pandemic by the World Health Organization because of its alarming levels of spread, severity and infection, and the United States soon had the highest number of confirmed cases and deaths in the world. But the threat isn’t over. COVID-19 is still lurking and waiting to infect new victims, and there are no approved therapeutics and vaccines in sight.

There’s an urgent need to prevent and treat COVID-19, and six scientists in the Institute for Biomedical Sciences have teamed up to develop effective therapeutics and vaccines, combining their expertise in life-threatening, infectious diseases and inflammatory diseases to get the crucial task done.

The scientific SWAT team – with experts on Ebola virus, influenza viruses, respiratory syncytial viruses and other infectious and inflammatory diseases – is working around the clock to conquer one of the most treacherous diseases in human history.

“We’re taking advantage of the strategies we have developed in the past studying other life-threatening viruses and using the lessons we have learned to develop effective therapeutics for fighting COVID-19,” said Jian-Dong Li, director of the Institute for Biomedical Sciences and a Georgia Research Alliance Eminent Scholar in Inflammation and Immunity at Georgia State. “Also, while developing therapeutics is urgently needed, vaccines are absolutely required for preventing people from getting this disease. Because of the time that vaccine development takes, our scientists have already started to take action to develop effective vaccines. Our strengths, experience and past lessons put us in a better position to solve this global crisis.”

Silvas 13WEB

Jesus Silvas, a postdoctoral research associate in Christopher Basler’s lab, is working on research to identify candidate therapeutics that inhibit SARS-CoV-2, the virus that causes COVID-19.

POTENTIAL CURES
Although the work of the institute’s scientists has focused on understanding and developing therapeutics for other pathogens, their approaches are likely applicable to COVID-19. Three researchers are working to develop treatments for COVID-19.

Christopher Basler, professor and director of the Center for Microbial Pathogenesis, and also a Georgia Research Alliance Eminent Scholar in Microbial Pathogenesis, is seeking to identify candidate therapeutics that inhibit viral genome replication of SARS-CoV-2. He will apply lessons and strategies learned from his work with Ebola virus to inhibit SARS-CoV-2 using a variety of approaches. Basler is also collaborating with clinical investigators to better understand the progression of COVID-19 in human patients.

In previous work, the world-renowned virologist found that a small molecule compound that inhibits Ebola virus also had activity in cell culture against Middle Eastern respiratory syndrome (MERS), which is similar to COVID-19 and caused sporadic disease in the Middle East for several years.

“We prevented growth of the virus outside the context of an animal,” Basler said. “You would expect that what combats and inhibits one coronavirus may act against another coronavirus.”

For his laboratory studies, Basler will collaborate with scientists at Sanford Burnham Prebys Medical Discovery Institute in California and several other leading institutions.

Richard Plemper, a Distinguished University Professor, has previously developed effective therapeutics to control influenza by inducing genetic error catastrophe in the virus, leading to the virus’ death. A compound developed in collaboration with Emory Institute for Drug Development has been chosen as a therapeutic candidate for clinical testing against COVID-19. Plemper now applies his ferret and human airway epithelium organoid infection models to SARS-CoV-2 and will conduct drug screening studies to determine dosing and efficacy.

Lea más publicaciones relacionadas [título_original] en la misma categoría

Somos un pequeño grupo de personas apasionadas que han estado escribiendo artículos dentales durante los últimos años. Creemos que una buena salud oral es la clave para una vida feliz y saludable. Nuestro objetivo es proporcionar información precisa y actualizada sobre todos los aspectos de la odontología para que nuestros lectores puedan tomar decisiones informadas sobre su salud bucal.
Sabemos que elegir un dentista o un tratamiento dental puede ser abrumador, pero esperamos que nuestros artículos ayuden a que el proceso sea un poco más fácil.
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